A Record Based Study on Various Factors Affecting The Choice Of Intra-Uterine Contraceptive Device In Ahmedabad City

Background:Unplanned pregnancy may be the reason of many neonatal and maternal adverse effects. The objective is to study various factors affecting IUCD (temporary contraceptive method) preference. Material And Methods:A record based study of data of 483 couples selecting IUCD, during the one year period was collected with permission from tertiary care hospital. Result:The most common group preferring IUCD was 21-30 years (mean age-females-26 years and males-30 years).Majority having 2 children opted for IUCD while only 1 couple opted for IUCD without any child. Out of the total, 42% opted PPIUCD, 42% interval IUCD and 16% PAIUCD. Among lower age and up to primary educated groups, majority opted for PPIUCD. Among higher age and educated groups, majority opted for interval IUCD. PAIUCD proportion was higher in less educated females. Majority ofMuslims preferred PPIUCD while Hindus, interval IUCD. The association of type of IUCD with age, number of children and religion was found significant while with education, it was in-significant. Conclusion:The use and type of IUCD preferred depends on various factors such as age of male and female, number of children and religion of couples.

A Record Based Study On Various Factors Affecting The Choice Of Intra-Uterine Contraceptive Device In Ahmedabad City

Background:Unplanned pregnancy may be the reason of many neonatal and maternal adverse effects. The objective is to study various factors affecting IUCD (temporary contraceptive method) preference. Material And Methods:A record based study of data of 483 couples selecting IUCD, during the one year period was collected with permission from tertiary care hospital. Result:The most common group preferring IUCD was 21-30 years (mean age-females-26 years and males-30 years).Majority having 2 children opted for IUCD while only 1 couple opted for IUCD without any child. Out of the total, 42% opted PPIUCD, 42% interval IUCD and 16% PAIUCD. Among lower age and up to primary educated groups, majority opted for PPIUCD. Among higher age and educated groups, majority opted for interval IUCD. PAIUCD proportion was higher in less educated females. Majority ofMuslims preferred PPIUCD while Hindus, interval IUCD. The association of type of IUCD with age, number of children and religion was found significant while with education, it was in-significant. Conclusion:The use and type of IUCD preferred depends on various factors such as age of male and female, number of children and religion of couples

Modification Of Gums By Periodate Oxidation: A Natural Cross-Linker

Scientists throughout the world are in search of novel modified biopolymer to fabricate smart drug delivery systems based on hydrogel formulations using several cross-linkers like glutaraldehyde, glyoxal, epichlorhydrin, adipic acid dihydrazide, carbodiimide, genipin, etc. Agents that are fused into the polymeric structure like isocyanates, glutaraldehyde, polyepoxides, etc., and are extremely toxic in nature. In addition, these are susceptible to percolate out into the body on biodegradation of polymeric structure. As an alternative to these toxic cross-linking agents, the periodate-Schiff base staining technique is widely being used for cross-linking in biology and biochemistry. The mechanism of this cross-linking technique is based on the reaction in-between the Schiff reagent and the aldehydes produced via the periodate oxidation. During the past few decades, several researchers have already been studied on the natural gums and also, developed their dialdehyde derivatives via the periodate oxidation technique. These periodate oxidized gums are being used to cross-link gelatin, other proteins and chitosan to develop various smart systems for drug delivery, tissue engineering, wound dressing, edible films, etc. The current review presents a comprehensive discussion of the available reported literature on the periodate oxidation of various gums and their use as natural cross-linker.

Pleomorphic Adenoma of Both Hard And Soft Palate - A Case Report.

Pleomorphic adenoma of major salivary gland like parotid is most common and generally it affect the superficial lobe of the gland. It sometime affect the minor salivary gland of different structure of face. It is rarely seen in minor salivary gland of the hard and soft palate . Surgery with negative margins does not lead to recurrence. We have encountered a pleomorphic adenoma of minor salivary gland of posterior part of hard palate in young female patient and it was excised with definitive margin with no recurrence. The defect was left to granulate of itself uneventfully.

Lymphatic filariasis in Khurda district of Orissa, India: an epidemiological study.

A cross-sectional survey was undertaken to determine the prevalence of disease due to lymphatic filariasis in Khurda district of Orissa, India. The total disease attributable to filariasis was significantly higher in males (14.79%) than females (10.04%). However, elephantiasis is more prevalent in females, and adenolymphangitis is more prevalent in males than their counterparts. The prevalences of various forms of the disease are age dependent in both sexes. About one-seventh of men and women of higher age groups suffered from chronic debilitation forms of the disease. The study suggests that overt clinical forms of lymphatic filariasis constitute a major public health problem in the study area.

Metronidazole relieves symptoms in irritable bowel syndrome: the confusion with so-called 'chronic amebiasis'.

BACKGROUND: Metronidazole is often administered to patients with irritable bowel syndrome with an erroneous diagnosis of 'chronic amebiasis'. AIMS: To assess how patients with irritable bowel syndrome respond to metronidazole in the absence of amebae in their stools. METHODS: We randomly allocated 45 patients (35 men; aged 15-59 years) with irritable bowel syndrome to receive isapghul (10 g bid x 60 days), metronidazole (400 mg tid X 10 days, followed by placebo x 50 days), or placebo (1 capsule bid x 60 days). Symptoms were evaluated and scored on days 0, 15, 30, 45 and 60. Rectosigmoid manometry was performed in 5 of 15 patients in each group on days 0 and 60. RESULTS: There was a significant time effect and treatment effect on the symptom scores in all groups (isapghul > metronidazole > placebo); total score decreased from mean 25.8, 24.0 and 24.6 on day 0 to 7.2, 10.9 and 18.1 on day 60, respectively. Severity, duration and frequency of pain; and mucus in stool were all significantly reduced in all treatment groups (p < 0.001 for each). Treatment with isapghul increased the mean amplitude of propagated activity from 26.2 mmHg to 30.1 mmHg at 20 cm (p < 0.025) and from 23.1 mmHg to 27.4 mmHg at 10 cm (p < 0.05) from the anal verge, as well as the total duration of propagated activity at both sites (p < 0.05), with decrease in number of propagated contractions per 10 min (p < 0.025). Metronidazole and placebo had no effect on manometric findings. CONCLUSIONS: Metronidazole provides symptom relief in irritable bowel syndrome, without affecting rectosigmoid motility. This symptom response may be misinterpreted as supporting a diagnosis of 'chronic amebiasis'.

Determinant analysis and interaction studies on monoclonal antibodies to bovine IgG1 and IgG2.

Two mouse monoclonal antibodies SKb1 and SKb6 were prepared by fusion of myeloma cells with spleen cells of female Balb/c mouse immunized with a mixture of bovine IgG1 and IgG2. In radioimmunoassay, SKb1 bound specifically to IgG2 but SKb6 reacted with both IgG1 and IgG2 molecules. In the competition experiments, heavy chain isolated from bovine IgG could inhibit the binding of 125I-IgG1 and 125I-IgG2 to SKb6, while it failed to inhibit the binding of 125I-IgG2 to SKb1. The epitope reacting with SKb1 was found to be present not only on bovine IgG2 but also on goat IgG and was not present on IgG molecules isolated from the serum of rabbit, rat, sheep, horse, human and monkey. Similarly, the epitope reacting to SKb6 was found to be present on bovine IgG1 and IgG2 and also on IgG molecules isolated from goat and sheep serum but was absent in the IgG molecules isolated from the serum of rabbit, rat, horse, human and monkey. The association constants of the interactions of SKb1 with 125I-IgG2 and of SKb6 with 125I-IgG1 and 125I-IgG2, determined by Scatchard analysis, Steward-Petty plot and Sips plot, were found to be in the order of 10(8)-10(10) L/M. The association constants were determined at varying temperatures to obtain the thermodynamic parameters. The enthalpy (delta H0) and entropy (delta S0) values for the above antigen-antibody interactions were in the range of 9.15-15.96 kcal/mole and 36.96-41.15 eu/mole respectively. The heterogeneity indices for similar interactions determined by Sips equation were consistent with the expected values for binding of monoclonal antibodies with homogeneous protein determinants.